Frequently asked
questions about SUNOSI

SUNOSI is a once-daily prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (OSA). It is a wake-promoting agent and is made of a medication called solriamfetol. Learn more about SUNOSI.

  • SUNOSI does not treat the cause of obstructive sleep apnea or take the place of your continuous positive airway pressure (CPAP). It is important that you continue to use your treatments as prescribed by your doctor.
  • It is not known if SUNOSI is safe and effective in children.

SUNOSI was approved by the FDA on March 20, 2019.

SUNOSI improved wakefulness for up to 9 hours when measured at 12 weeks in two clinical studies. The 75 mg dose did not show improvement across 9 hours for people with narcolepsy.

SUNOSI started working at one hour when measured at 12 weeks in two clinical studies. The 75 mg dose did not show improvement at one hour for people with narcolepsy. It is important to talk to your doctor about how quickly SUNOSI can work for you.
Learn more about the study results.

SUNOSI is thought to act on 2 areas in the brain that help keep you awake during the day.

  • Take SUNOSI exactly as your healthcare provider tells you to. Do not change your dose of SUNOSI without talking to your healthcare provider.
  • Your healthcare provider may need to change the dose of SUNOSI to find the right dose for you. This is normal and may be a part of the process.
  • Take SUNOSI by mouth 1 time each day when you first wake up. Avoid taking SUNOSI within 9 hours of your planned bedtime. If you take SUNOSI too close to your bedtime, you may find it harder to go to sleep.
  • SUNOSI can be taken with or without food.
  • Depending on your prescribed dose, your healthcare provider may tell you to swallow your SUNOSI tablet whole or split the SUNOSI tablet in half at the score line in the middle of the tablet. Ask your healthcare provider if you have questions about how to split the SUNOSI tablet in half the right way.
  • If you take too much SUNOSI, call your healthcare provider or go to the nearest hospital emergency room right away.

The most common side effects experienced with SUNOSI include headache, nausea, decreased appetite, anxiety, and insomnia. These are not all the possible side effects of SUNOSI. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

Only you and your healthcare provider can decide if SUNOSI is right for you. If you’ve been diagnosed with excessive daytime sleepiness due to obstructive sleep apnea or narcolepsy and still feel tired during the day, ask your doctor about SUNOSI using the Wake-Up Call Questionnaire.

Talk to your healthcare provider if you are pregnant or plan on becoming pregnant, as you can work together to decide if taking SUNOSI is right for you. There is a pregnancy registry for women who take SUNOSI during pregnancy that seeks to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry. For more information or to participate in the registry, call 1-877-283-6220 or go to www.SunosiPregnancyRegistry.com.

There are many types of healthcare providers who can help determine if SUNOSI is right for you. You can speak with your primary care physician or one of the following specialists: sleep specialist, pulmonologist, neurologist, or psychiatrist.

SUNOSI is available at most major retail pharmacies. If you have a valid prescription from your doctor and your pharmacy doesn’t have SUNOSI in stock, ask the pharmacist if they can order it for you. We can also help answer questions you have about getting SUNOSI, savings, or info about your condition. Talk to a Nurse Navigator.

Based on your eligibility, you may be able to pay as little as $9 for a one-month supply of SUNOSI. Click here to get a SUNOSI Savings Card. The cost of SUNOSI will vary depending on whether or not you have insurance, and if so, what type of insurance.

Axsome Therapeutics, Inc. provides a variety of patient support services for SUNOSI. If you have questions or need assistance paying for your medication, SUNOSI On My Side may be able to help. You can call SUNOSI On My Side Monday-Friday, 8 AM-8 PM ET, at 1-800-805-8621 for more information about paying for your prescription.

Axsome Therapeutics, Inc. provides a variety of patient support services for SUNOSI. If you have questions or need assistance paying for your medication, SUNOSI On My Side may be able to help. You can call SUNOSI On My Side Monday-Friday, 8 AM-8 PM ET, at 1-800-805-8621 for more information about paying for your prescription.

For patients with Medicare or Medicaid, SUNOSI may be available through your government insurance plan.

  • Your doctor will likely need to complete either a Prior Authorization or a Medical Exception form and submit it to your Medicare or Medicaid plan administrator
  • CoverMyMeds can help simplify and streamline this Approval process for your doctor. Access CoverMyMeds
  • If approved, your Medicare or Medicaid plan will cover SUNOSI, and depending on your benefit design, you will have either a coinsurance payment, a low copay, or no copay associated with SUNOSI

Use this discussion starter as a guide for talking to your doctor about SUNOSI.

Are you taking SUNOSI for excessive daytime sleepiness due to obstructive sleep apnea or narcolepsy? We’d love to hear your success story. Send us an email at SunosiShareMyStory@axsome.com.

Yes! Go to the SUNOSI Resources page to learn more and download the SUNOSI brochure.

If you have questions about EDS or SUNOSI, you can chat with a Nurse Navigator to get answers. Nurse Navigators can also help you schedule doctor appointments and save on SUNOSI. Start a chat.

Still have questions? Talk to a Nurse Navigator.

INDICATION AND IMPORTANT SAFETY INFORMATION Expand ISI

Do not take SUNOSI if you are taking, or have stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI).

Before taking SUNOSI, tell your doctor about all of your medical conditions, including if you:

  • have heart problems, high blood pressure, kidney problems, diabetes, or high cholesterol.
  • have had a heart attack or a stroke.
  • have a history of mental health problems (including psychosis and bipolar disorders), or of drug or alcohol abuse or addiction.
  • are pregnant or planning to become pregnant. It is not known if SUNOSI will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if SUNOSI passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SUNOSI.
INDICATION AND IMPORTANT SAFETY INFORMATION
What is SUNOSI? SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (OSA).
  • SUNOSI does not treat the underlying cause of OSA and SUNOSI does not take the place of any device prescribed for OSA, such as a continuous positive airway pressure (CPAP) machine. It is important that you continue to use these treatments as prescribed by your healthcare provider.
IMPORTANT SAFETY INFORMATION

Do not take SUNOSI if you are taking, or have stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI).

Before taking SUNOSI, tell your doctor about all of your medical conditions, including if you:
  • have heart problems, high blood pressure, kidney problems, diabetes, or high cholesterol.
  • have had a heart attack or a stroke.
  • have a history of mental health problems (including psychosis and bipolar disorders), or of drug or alcohol abuse or addiction.
  • are pregnant or planning to become pregnant. It is not known if SUNOSI will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. SUNOSI passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SUNOSI.
What are the possible side effects of SUNOSI?
SUNOSI may cause serious side effects, including:
Increased blood pressure and heart rate. SUNOSI can cause blood pressure and heart rate increases that can increase the risk of heart attack, stroke, heart failure, and death. Your doctor should check your blood pressure before, and during, treatment with SUNOSI. Your doctor may decrease your dose or tell you to stop taking SUNOSI if you develop high blood pressure that does not go away during treatment with SUNOSI.
Mental (psychiatric) symptoms including anxiety, problems sleeping (insomnia), irritability, and agitation. Tell your doctor if you develop any of these symptoms. Your doctor may change your dose or tell you to stop taking SUNOSI if you develop side effects during treatment with SUNOSI.

The most common side effects of SUNOSI include:

  • •headache
  • •nausea
  • •decreased appetite
  • •anxiety
  • •problems sleeping
These are not all the possible side effects of SUNOSI. Call your doctor for advice about side effects.
SUNOSI (solriamfetol) is available in 75 mg and 150 mg tablets and is a federally controlled substance (CIV) because it contains solriamfetol that can be a target for people who abuse prescription medicines or street drugs. Keep SUNOSI in a safe place to protect it from theft. Never give or sell your SUNOSI to anyone else because it may cause death or harm them and it is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Medication Guide.

SUN CON ISI 06/2023