Excessive daytime sleepiness (EDS) due to obstructive sleep apnea (OSA) can disrupt many parts of your life

Excessive daytime sleepiness (EDS) due to obstructive sleep apnea (O.S.A.) can disrupt many parts of your life 9/10 people with EDS due to O.S.A. reported problems with their work, social life, and relationships due to their symptoms.* 9/10 people with EDS due to O.S.A. reported problems with their work, social life, and relationships due to their symptoms.*
People with EDS due to OSA are ~37% more likely to have depression and ~50% more likely to have anxiety compared to people with OSA without EDS.†

SUNOSI is not indicated to treat depression or anxiety.

*Findings based on a study of focus groups conducted with 42 individuals experiencing EDS due to O.S.A.

†Findings based on a real-world study of 476 individuals, including individuals with EDS and those without EDS.

CPAP alone might not be enough to
improve wakefulness

Continuous positive airway pressure (CPAP) is a machine that is commonly used to help treat O.S.A.
52 percent of people with O.S.A. who use CPAP reported feeling sleepy during the day‡
‡Findings based on a clinical trial of 174 patients with moderate to severe O.S.A.

This is because OSA can disrupt chemicals in the brain, called neurotransmitters, that keep you
awake during the day. This may cause EDS in some people. Treating the disruptions can help manage EDS.

Disruption to your airways

When your airways repeatedly get blocked while you sleep, it can cause shallow breathing or cause your breathing to repeatedly stop. CPAP helps treat this disruption.

Disruption to your brain

Repeated sleep interruptions can harm parts of the brain that control feeling awake or sleepy. This can disrupt the activity of chemicals (neurotransmitters) in the brain, which can make you feel sleepy during the day. Wake-promoting agents, like SUNOSI, are thought to treat these disruptions.

SUNOSI is thought to improve wakefulness by increasing the activity of 2 wakefulness neurotransmitters: dopamine and norepinephrine.§

§The exact way that SUNOSI works to treat EDS due to OSA is unclear.

Download our quick reference guide to EDS due to O.S.A.

If EDS is making it hard to get through
your day, you’re not alone

When I started to feel sleepy more often, I struggled to pay attention. As my law career progressed, I gained more responsibility, but as my sleepiness grew, my performance at work began to suffer.”

Heath, a real SUNOSI patient

Here’s how EDS due to OSA is diagnosed

Your healthcare provider will conduct a sleep study to confirm a diagnosis of O.S.A.

To diagnose EDS, your discussion with your healthcare provider may include answering a quiz called the Epworth Sleepiness Scale (ESS). In this quiz, you’ll answer questions about your likelihood of falling asleep in everyday situations

Many types of healthcare providers can help diagnose EDS due to O.S.A., including:
  • primary care doctor
  • sleep specialist
  • pulmonologist
  • neurologist
  • psychiatrist
  • nurse practitioner
  • physician assistant
Answer the Wake-Up Call Questionnaire

Five simple questions can help you start a conversation with your healthcare provider.

Start questionnaire
As a reminder, SUNOSI does not treat the cause of O.S.A. or take the place of your CPAP. Continue to use any treatments or devices as prescribed by your healthcare provider.
See what SUNOSI offers

Do not take SUNOSI if you are taking, or have stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI).

Before taking SUNOSI, tell your doctor about all of your medical conditions, including if you:

  • have heart problems, high blood pressure, kidney problems, diabetes, or high cholesterol.
  • have had a heart attack or a stroke.
  • have a history of mental health problems (including psychosis and bipolar disorders), or of drug or alcohol abuse or addiction.
  • are pregnant or planning to become pregnant. It is not known if SUNOSI will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if SUNOSI passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SUNOSI.
INDICATION AND IMPORTANT SAFETY INFORMATION
SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (OSA). What is SUNOSI? SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (O.S.A.).
  • SUNOSI does not treat the underlying cause of O.S.A. and SUNOSI does not take the place of any device prescribed for O.S.A., such as a continuous positive airway pressure (CPAP) machine. It is important that you continue to use these treatments as prescribed by your healthcare provider.
IMPORTANT SAFETY INFORMATION

Do not take SUNOSI if you are taking, or have stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI).

Before taking SUNOSI, tell your doctor about all of your medical conditions, including if you:
  • have heart problems, high blood pressure, kidney problems, diabetes, or high cholesterol.
  • have had a heart attack or a stroke.
  • have a history of mental health problems (including psychosis and bipolar disorders), or of drug or alcohol abuse or addiction.
  • are pregnant or planning to become pregnant. It is not known if SUNOSI will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. SUNOSI passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SUNOSI.
What are the possible side effects of SUNOSI?
SUNOSI may cause serious side effects, including:
Increased blood pressure and heart rate. SUNOSI can cause blood pressure and heart rate increases that can increase the risk of heart attack, stroke, heart failure, and death. Your doctor should check your blood pressure before, and during, treatment with SUNOSI. Your doctor may decrease your dose or tell you to stop taking SUNOSI if you develop high blood pressure that does not go away during treatment with SUNOSI.
Mental (psychiatric) symptoms including anxiety, problems sleeping (insomnia), irritability, and agitation. Tell your doctor if you develop any of these symptoms. Your doctor may change your dose or tell you to stop taking SUNOSI if you develop side effects during treatment with SUNOSI.

The most common side effects of SUNOSI include:

  • •headache
  • •nausea
  • •decreased appetite
  • •anxiety
  • •problems sleeping
These are not all the possible side effects of SUNOSI. Call your doctor for advice about side effects.
SUNOSI (solriamfetol) is available in 75 mg and 150 mg tablets and is a federally controlled substance (CIV) because it contains solriamfetol that can be a target for people who abuse prescription medicines or street drugs. Keep SUNOSI in a safe place to protect it from theft. Never give or sell your SUNOSI to anyone else because it may cause death or harm them and it is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

SUN CON ISI 06/2023

Please see Medication Guide.
INDICATION
SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (OSA). What is SUNOSI? SUNOSI (solriamfetol) is a prescription medicine used to improve wakefulness in adults with excessive daytime sleepiness due to narcolepsy or obstructive sleep apnea (O.S.A.).
  • SUNOSI does not treat the underlying cause of O.S.A. and SUNOSI does not take the place of any device prescribed for O.S.A., such as a continuous positive airway pressure (CPAP) machine. It is important that you continue to use these treatments as prescribed by your healthcare provider.
IMPORTANT SAFETY INFORMATION

Do not take SUNOSI if you are taking, or have stopped taking within the past 14 days, a medicine used to treat depression called a monoamine oxidase inhibitor (MAOI).

Before taking SUNOSI, tell your doctor about all of your medical conditions, including if you:

  • have heart problems, high blood pressure, kidney problems, diabetes, or high cholesterol.
  • have had a heart attack or a stroke.
  • have a history of mental health problems (including psychosis and bipolar disorders), or of drug or alcohol abuse or addiction.
  • are pregnant or planning to become pregnant. It is not known if SUNOSI will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if SUNOSI passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SUNOSI.